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OJVRTM

Online Journal of Veterinary Research

 

Volume 26 (7): 486-498, 2022.


 

Effect of Salvia Rhytidia sage on cerebellum cells following ischemia-reperfusion in male Wistar rats

 

Maryam Farahmand, Mina Tadjali

 

School of Veterinary Medicine, Shiraz University, Shiraz, Iran

 

ABSTRACT

 

Farahmand M, Tadjali M., Effect of Salvia Rhytidia sage on cerebellum cells following ischemia-reperfusion in male Wistar rats, Onl J Vet Res., 26 (7): 486-498, 2022. We report effect of Salvia Rhytidia extract of (SR) in ameliorating cerebellar ischemia reperfusion (IR) injuries in Wistar rat. We used groups of five 250-350g Wistar rats each subjected to ischemia by ventral midline cervical incision and clamping of left common carotid and vertebral arteries for 10 min by Rumel tourniquet under general anesthesia. Five groups of 5 rats each were gavaged 3.2mg/kg Salvia Rhytidia extract (1), 50 mg silymarin (2) or saline (3) 72, 48, 24 and 0 h before surgery. Others were given extract 2h before and silymarin 2h after clamping. Controls consisted of normal and ischemic rats without treatment. Twenty four hours after rats were sacrificed and cerebellum removed for microscopy and histomorphometrical studies. Compared with controls, ischemia reperfusion reduced granular layer and Purkinje cells ~36% (P< 0.05) whereas in those given extract, cells remained as in controls. Results suggest Salvia Rhytidia may prevent injury of rat cerebellum comparable to silymarin.

 

Key words: Ischemia-reperfusion, Cerebellum, Salvia Rhytidia, Rat.


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