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OJVRTM
Online
Journal of Veterinary Research©
Volume 26 (7): 486-498, 2022.
Effect of Salvia
Rhytidia sage on cerebellum cells following ischemia-reperfusion
in male Wistar rats
Maryam Farahmand, Mina Tadjali
School of Veterinary
Medicine, Shiraz University, Shiraz, Iran
ABSTRACT
Farahmand M, Tadjali M., Effect of Salvia Rhytidia
sage on cerebellum cells following ischemia-reperfusion in male Wistar rats, Onl J Vet Res., 26 (7): 486-498, 2022. We report effect of Salvia Rhytidia extract of (SR) in ameliorating cerebellar ischemia
reperfusion (IR) injuries in Wistar rat. We used groups
of five 250-350g Wistar rats each subjected to ischemia by ventral midline cervical incision and clamping
of left common carotid and vertebral arteries for 10 min by Rumel
tourniquet under general anesthesia. Five
groups of 5 rats each were gavaged 3.2mg/kg Salvia Rhytidia extract (1), 50 mg silymarin (2)
or saline (3) 72, 48, 24 and 0 h before surgery. Others were given extract 2h
before and silymarin 2h after clamping. Controls consisted
of normal and ischemic rats without treatment. Twenty four hours after rats were sacrificed
and cerebellum removed for microscopy and histomorphometrical
studies. Compared with controls, ischemia reperfusion reduced granular layer
and Purkinje cells ~36% (P< 0.05) whereas in those given extract, cells remained as in controls. Results
suggest Salvia Rhytidia may prevent injury of
rat cerebellum comparable to silymarin.
Key words: Ischemia-reperfusion, Cerebellum, Salvia Rhytidia,
Rat.
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