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OJVRTM
Online Journal of Veterinary Research©
Volume
18(5): 405-414, 2014. Redacted 2017.
Effect
of salinomycin on tetracycline resistance in E.
coli
M
Dehghani1, S Hosseinzadeh2, H Rajaian1, SS
Shekarforoush2, Y Zolghadri1 and J Jalaei1
1Department(s)
of Basic Science and 2Food Hygiene, School of Veterinary Medicine,
Shiraz University, Iran
ABSTRACT
Dehghani M, Hosseinzadeh S, Rajaian
H, Shekarforoush SS, Zolghadri
Y, Jalaei J., Effect of salinomycin
on tetracycline resistance in E. coli, Onl J Vet
Res., 18(5): 405-414, 2014. Increasing rates of tetracycline resistance in
animals is being transmitted to humans. tetA is the most
prevalent resistant plasmid in E. coli with a prevalence rate of 62 %
based on MIC and gene screening. Ionophores used as
food additive to promote growth are reported to transmit antimicrobial
resistance genes such as tetA in
bacteria. A possible interaction of salinomycin with
tetracycline is described using in-vitro real time RT-PCR. Results
suggest that the growth of tetracycline resistant E. coli was
significantly reduced at 100 µg/ml of tetracycline in salinomycin
exposed bacteria. Salinomycin decreased the relative
transmission of the resistance genome (P < 0.001).
Keywords: Salinomycin, E. coli, Antibiotic resistance.
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