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OJVRTM

Online Journal of Veterinary Research

Volume 24 (1):66-73, 2020.


Acute and chronic effects of salinomycin on serum biochemical parameters in sheep.

 

Rajaian Ha, Nazifi S*b, Mohtarami Sa

 

Departments of aBasic Sciences and bClinical Studies, School of Veterinary Medicine, Shiraz University, PO Box 1731, Shiraz 71345, Iran

 

ABSTRACT

 

Rajaian H, Nazifi S, Mohtarami S., Acute and chronic effects of salinomycin on serum biochemical parameters in sheep, Onl J Vet Res., 24 (1):66-73, 2020. Salinomycin is used as a growth promoter for ruminants and coccidiostat in chickens and toxic effects can result from overdosing. We describe blood biochemistry in groups of 5 ewes each weighing 35-45 kg given 1, 2 and 4 mg/kg oral salinomycin twice daily for 35 days. Jugular blood was taken before and 1, 3, 5, 6, 12, 15, 19, and 26 days after administration for serum ALT, AST, CK, creatinine, calcium, phosphorus, sodium, potassium, chloride and total protein determined by conventional laboratory methods. One ewe each given 1 and 2mg/kg salinomycin and two given 4mg/kg, died within 3 days. At any dose and mostly during the first 5 days, we found increased (P < 0.05) serum ALT (~20-80%), AST(~100%), CK (~100-150%), creatinine (~40%) potassium (16%), phosphorous and BUN (~150-200%) but decreased chloride (~-20%) and sodium (~-26%) but no change in protein or calcium levels. Most values returned to control values by days 12 to 26 but results suggested initial 0-3 day transient liver and/or cardiac toxicity at any dose

 

Key words: Salinomycin, Serum biochemical parameters , fat-tailed sheep.


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