2020-2032. All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


Online Journal of Veterinary Research

Volume 24 (1):66-73, 2020.

Acute and chronic effects of salinomycin on serum biochemical parameters in sheep.


Rajaian Ha, Nazifi S*b, Mohtarami Sa


Departments of aBasic Sciences and bClinical Studies, School of Veterinary Medicine, Shiraz University, PO Box 1731, Shiraz 71345, Iran




Rajaian H, Nazifi S, Mohtarami S., Acute and chronic effects of salinomycin on serum biochemical parameters in sheep, Onl J Vet Res., 24 (1):66-73, 2020. Salinomycin is used as a growth promoter for ruminants and coccidiostat in chickens and toxic effects can result from overdosing. We describe blood biochemistry in groups of 5 ewes each weighing 35-45 kg given 1, 2 and 4 mg/kg oral salinomycin twice daily for 35 days. Jugular blood was taken before and 1, 3, 5, 6, 12, 15, 19, and 26 days after administration for serum ALT, AST, CK, creatinine, calcium, phosphorus, sodium, potassium, chloride and total protein determined by conventional laboratory methods. One ewe each given 1 and 2mg/kg salinomycin and two given 4mg/kg, died within 3 days. At any dose and mostly during the first 5 days, we found increased (P < 0.05) serum ALT (~20-80%), AST(~100%), CK (~100-150%), creatinine (~40%) potassium (16%), phosphorous and BUN (~150-200%) but decreased chloride (~-20%) and sodium (~-26%) but no change in protein or calcium levels. Most values returned to control values by days 12 to 26 but results suggested initial 0-3 day transient liver and/or cardiac toxicity at any dose


Key words: Salinomycin, Serum biochemical parameters , fat-tailed sheep.