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OJVRTM
Online Journal of Veterinary Research©
Volume
23 (11):1137-1144, 2019.
Effect of
phenobarbital and chloramphenicol on toxicity of salinomycin
LD50 dose in Ross broilers and layers.
H Rajaiana*,
S Nazifib , M Aberumandia , J Jalaeia
aDepartments of Pharmacology and
bClinical Pathology, School of Veterinary
Medicine, Shiraz University, Shiraz , Iran
ABSTRACT
Rajaian H, Nazifi
S, Aberumandi M, Jalaei J., Effect of phenobarbital and chloramphenicol on
toxicity and LD50 of salinomycin in
chickens, Onl J Vet Res., 23 (11):1137-1144,
2019. We determined
mortality
in broilers and layers given salinomycin at a dose
equal to LD50 after administration of chloromphenicol
and phenobarbital. Two and 4 days before oral salynomycin
three groups of 17 broiler and 22 broilers each were injected IM 2 chloramphynecol (group 1) with phenobarbital (2) or saline
(3). Wing vein blood was taken at 1, 3 and 5 days after salinomycin
for serum creatinine, aspartate and alanine transaminases, calcium, sodium,
potassium, chloride and glucose. LD50s of salinomycin
in broiler chickens was ~108 and in layers ~104 mg/kg body weight, respectively.
Compared with controls we observed reduced mortality (~9%) in layers given
chloramphenicol or phenobarbital and broilers dosed chloramphenicol (~15%).
However, in broilers given phenobarbital mortality was reduced by a much higher
~32%. There were no significant changes in biochemical parameters in broilers
or layers. The LD50s of salinomycin in
broiler chickens and laying hens obtained in this study are more or less
similar to the values reported in the literature. The lowering of the death
rate by phenobarbital in broiler chickens receiving LD50 dose of salinomycin is probably due to the inducing effect of
phenobarbital on liver microsomal enzymes.
Key words: Salinomycin , LD50 , Chickens, Chloramphenicol, Phenobarbital.
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