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OJVRTM
Online Journal of
Veterinary Research©
Volume 7:26-32, 2003. Redacted 2018.
Sub-acute oral toxicity
of Salinomycin in broiler chicks
Arun KHS, Manjuna HS1, Reddy KS, Reddy
BA.
Department of Pharmacology and
Toxicology, College of Veterinary Science, ANGRAU, Rajendranagar,
Hyderabad, India. @ Dept of LPM. 1Biochemist, Biocon
India Ltd., Bangalore, India.
SUMMARY
Arun KHS, Manjuna HS, Reddy KS, Reddy BA. Sub-acute oral toxicity of Salinomycin in
broiler chicks, Onl J Vet Res., 7 :
26-32, 2003. The effects of 120 ppm salinomycin
in feed (sub-acute oral toxicity) on clinical signs, tissues and serum
biochemistry of broiler chicks was evaluated. Symptoms ranged from
in-coordination, lethargy, leg weakness, diarrhea, reduced feed intake and
weight loss. Sternal recumbency with neck, wings and
hind limbs outstretched were characteristic and prominent by the 4th week of salinomycin exposure. Extensive pathology occurred in
skeletal muscle, heart, lungs, kidney, liver, intestines and bursa. Serum
alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and
lactase dehydogenase, urea, creatinine and
cholesterol increased whereas total protein, albumin and globulin
decreased. There were no significant changes in values taken from control
birds or those fed 60 ppm salinomycin.
KEY-WORDS: Salinomycin,
biochemical parameters, and toxicity.