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OJVRTM
Online Journal of
Veterinary Research©
Volume 12 (2)
:15-22, 2008. Redacted
extensively 2018.
Pathological changes associated with experimental salinomycin
toxicosis in calves.
Rajaian Ha
, Nazifi S*b
, Mansourian Mc , Sepehrimanesh Ma , Poorbaghi SLa , Ghezelbash Aa
a Departments
of Pharmacology and b Clinical Pathology, School of Veterinary
Medicine, Shiraz University, Shiraz 71345-1731, Iran cDepartment of Veterinary
Medicine, Islamic Azad University of Bojnourd, Bojnourd, Iran
ABSTRACT
Rajaian
H, Nazifi
S, Mansourian M, Sepehrimanesh M, Poorbaghi SL, Ghezelbash A, Pathological changes associated with
experimental salinomycin toxicosis
in calves, Onl J Vet Res., 12 (2) :15-22, 2008. Salinomycin, an ionophore is given to ruminants as a growth
promoter and for preventing coccidiosis. There are some reports of poisoning in animals when
salinomycin is given in high concentrations in feeds
by error, and in humans due to occupational and misuse reasons. There is no
specific cure for ionophore poisoning apart from
supportive treatment. Pathological and biochemical parameters changes in
calves intoxicated by salinomycin are described with
the purpose of developing a treatment. Eleven calves (90 to 130kg) were
randomly divided into three groups and doses of 5 (males; n=4), 4 (males; n=3) and
4 (females; n=4) mg/kg of salinomycin were orally
administered twice daily for two consecutive days. Postmortem of two animals
revealed congestion and edema of skeletal muscles, swelling and hemorrhage in
peripheral lymph nodes, hydrothorax, and hydropericardium,
petechial hemorrhages in fat tissues of heart base, severe pulmonary congestion
and edema, large pale kidney and swelling of liver with mild to moderate
yellowish appearance. Histopathologic examination revealed pulmonary congestion
and edema with hyalinized thrombi in some of
capillaries, myocardial degeneration and necrosis without any inflammatory
reaction. Hepatocytes, renal tubules, sciatic nerves, and muscles were among
other tissues that showed histological changes.
Key words:
Salinomycin toxicosis, Pathological
lesions, Calves.