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Online Journal of Veterinary Research©

 

 12 (2) :47-51, 2008.  Extensively redacted 2018.

Spontaneous hepatic rupture in a cat with hepatic amyloidosis and inflammatory bowel disease

 

Abbaszade M1, Selk Ghaffari M2, Dezfoulian O3, Aledavood SJ1 and Jahanzad I. 4

 

 

1Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran. 2Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University-Karaj Branch.  3Department of Pathology, Faculty of Veterinary Medicine, University of Lorastan, Khorramabad, 4Department of pathology, Faculty of Medicine, University of Medical Sciences of Tehran, Tehran, Iran

 

ABSTRACT

 

Abbaszade M, Selk Ghaffari M, Dezfoulian O, Aledavood SJ and Jahanzad I. Spontaneous hepatic rupture in a cat with hepatic amylodosis and inflammatory bowel disease, Onl J Vet Res, 12 (2) :47-51, 2008. A 7-year-old cross-bred cat was treated with metronidazole for chronic diarrhea, but suddenly died ten days after recommencement of treatment. The owner reported that the onset of clinical signs were frequent diarrhea, vomiting and slow weight loss. On postmortem examination, the abdominal cavity was filled with bloody fluid and several blood clots. Under microscopic examination, extensive deposition of pink-reddish material was observed in parenchyma of the liver and sinusoids. The lamina propria of small intestine was infiltrated by largely mononuclear inflammatory cells mostly lymphocytes and plasma cells. On immunohistochemical staining, amyloid deposits revealed Amyloid A in hepatocytes and disse spaces of the liver and in the cytoplasm of renal tubuler cells but were negative for kappa and lambda chain antibodies.

 

KEY WORDS: hepatic rupture, amyloidosis, inflammatory bowel disease, cat.

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