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OJVRTM
Online Journal of Veterinary Research©
Volume 11(2):38-43, 2007. Redacted 2018.
Phenyl phosphorodiamidate
(PPD) adversely affects electrophysiology of rumen epithelium in sheep
Abdoun K1, Martens H2
1Department of Physiology, Faculty of
Veterinary Medicine, University of Khartoum, 13314 Shambat,
Sudan 2Institute of Veterinary Physiology, Faculty of Veterinary
Medicine, Free University of Berlin, Oertzenweg 19b,
14163 Berlin, Germany
ABSTRACT
Abdoun K, Martens H, Phenyl phosphorodiamidate
(PPD) adversely affects the electrophysiology of the rumen epithelium in Sheep,
Onl J Vet Res 11(2):38-43, 2007. The effect of
mucosal application of 1mmol/l phenyl phosphorodiamidate
(PPD) on the electrophysiology of isolated rumen epithelium was studied in
vitro using a conventional Ussing chamber
technique. Thirty-six isolated rumen epithelium samples from 5 sheep of
different breeds, age and sex and solely fed on hay were used. Mucosal
application of phenyl phosphorodiamidate, which has
an application in improving the utilization of dietary urea in ruminants
nutrition, on the mucosal side of ruminal epithelial tissues resulted in a
significant (p<0.05) reduction of the transepithelial
potential difference (PDt) and epithelial short
circuit current (Isc), and a significant (p<0.05)
elevation of the epithelial tissue conductance (Gt). Phenyl phosphorodiamidate
could thus impair the barrier and transport function of the rumen epithelium.
KEY-WORDS: Electrophysiology; Phenyl phosphorodiamidate;
Rumen; Sheep.
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