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 Online Journal of Veterinary Research

Volume 22 (8):659-668, 2018.

Effect of Rosa damascene gel on cutaneous wound healing and tension forces in Sprague Daley rats.


Nasser Vajdi, Aboutorab Tabatabaei-Naeini, Alireza Raayat Jahromi


Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran




Vajdi N, Tabatabaei-Naeini A, Jahromi AR., Effect of Rosa damascene gel on cutaneous wound healing and tension forces in Sprague Daley rats. Onl J Vet Res., 22 (8):659-668, 2018. Rosa damascene mill has been shown to have beneficial roles on wound healing but its effect is not yet clear. We describe effects of Rosa damascene mill extract gel on experimental cutaneous wound healing and tension forces in male rats. Under anesthesia, groups of 10 Sprague Daley a circular 1cm diameter skin area between the 1st thoracic vertebra 1cm proximal to the 1st lumbar was excised. The wound areas were then treated with topical 5% or 10% rose base gel spray daily for 7 days. Controls were treated with 0.2 % oxytetracycline spray or base gel sprays. Samples were excised for microscopy and tension force tests 10 and 21 days after surgery. By 21 days, compared with controls and 5% rose gel, we found that 10% rose gel improved re-epithelialization of stratum basalis, mature granulation tissue, hair follicles and sweat gland and tension forces compared with other groups. We found least fibroblasts but most vascularization at day 21 (P < 0.05) and lymphocytes highest (P < 0.05) at 10 days in rats sprayed 10% rosa gel. Tension force data (P < 0.05 ) supported subjective microscopy findings for rats treated with 10% rosa gel.


Keywords Rosa damascene mill, wound healing, rat. Raw data provided.