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OJVRTM
Online Journal
of Veterinary Research©
Volume
18(5): 420-427, 2014. Redacted 2017.
Effect of Rosa damascene
oil on ovarian tissue copper toxicity in NMRI mice
Ehsanollah Sakhaee1*, Reza Kheirandish2,
Ladan Emadi3, Mohammad Reza Esmaeili Nejad4, Hemad
Shafiei Bafti4
1Department(s) of
Clinical Sciences, 2Pathobiology, 3Basic Sciences, 4School
of Veterinary Medicine, Shahid Bahonar
University of Kerman, Kerman, Iran
ABSTRACT
Sakhaee E, Kheirandish R, EmadiL, Esmaeili Nejad MR, Bafti HS., Effect of
Rosa damascene oil on ovarian tissue copper toxicity in NMRI mice, Onl J Vet Res., 18(5): 420-427, 2014. Groups of 10
NMRI female mice each were gavaged 100 mg/kg copper
sulfate, 0.1 mg/kg Rosa damascene essential oil or 100mg/kg copper
sulfate with 0.1 R
damascene oil. Controls were gavaged
100ml/kg distilled water. Animals were sacrificed at 42 days and ovarian
lesions were evaluated against controls. Results suggested that treatment group
had fewer ovarian lesions, atretic follicles with
degenerative changes and apoptotic cells compared with controls.
Keywords: Rosa damascene; Copper poisoning;
Histopathology; Mice; Ovary.
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