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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 25 (9):623-630, 2021
Effect of chronic fenvalerate on cellular and humoral immunity induced
by rinderpest tissue culture vaccine in goats.
KK Singh1, MK Gupta2, Suruchi Kumari3, Sanjit Kumar4 and BK Roy5
1,2,4Department(s) of Veterinary Pathology, 3,5Pharmacology and Toxicology, College of Veterinary Science & A.H., Birsa Agricultural University, Ranchi, Jharkhand, India.
KK Singh, MK Gupta, Kumari S, Kumar S, Roy BK., Effect of chronic fenvalerate on cellular and humoral immunity induced by rinderpest tissue culture vaccine in goats, Onl J Vet Res., 25 (9):623-630, 2021. We describe effect of chronic fenvalerate toxicity on humoral and cellular immune responses induced by a tissue cultured rinderpest (TCRV) vaccine in goats. Chronic fenvalerate toxicity was induced in 7 goats by drenching 15mg/kg fenvalerate daily for 270 days. Five control goats were drenched saline. Both groups were vaccinated after 90 days. Humoral immunity was determined by Rinderpest Hemagglutination Inhibition (HAI) antibody titre on day 7, 14, 28, 90 and 190 post vaccination. Rinderpest HAI titres peaked 14 days after vaccination (P < 0.01)~66% in treated or controls. However, compared with controls, titres were much lower (-89%) in goats given fenvalerate up to 90 days suggesting suppression of immune response to TCVR vaccination. Concerning delayed hypersensitive skin reactions (DTH) after 175 days of vaccination, we found a ~10 fold increase in controls given spleen powder without allergen but only 5 fold injected spleen with allergen by 24h. Findings suggest that fenvalerate suppressed humoral and cellular immune to TCRV vaccine in goats.
Key Words: pyrethroids, immunity, suppression, rinderpest, vaccine.