2021-2033. All Rights Reserved. Online Journal of Veterinary Research . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


OJVRTM

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X

 

Volume 27 (2): 96-113, 2023.


Effect of rinderpest vaccine on immune markers and toxicity of pyrethroids in goats.

 

KK Singh1, MK Gupta2, Suruchi Kumari3, Sanjit Kumar4, BK Roy5

 

1,2,4Department of Veterinary Pathology, College of Veterinary Science & A.H., Birsa Agricultural University, Ranchi 834006, Jharkhand, India.

3,5Department of Pharmacology and Toxicology, College of Veterinary Science & A.H., Birsa Agricultural University, Ranchi, 834006, Jharkhand, India

 

ABSTRACT

 

Singh KK, Gupta MK, Kumari S, Kumar S, Roy BK., Effect of rinderpest vaccine on immune markers and toxicity of pyrethroids in goats, Onl J Vet Res., 27 (2): 96-113, 2023. Authors report effect of chronic fenvalerate toxicity on humoral and cellular immune response induced by rinderpest vaccine in goats. Toxicity was induced by 15mg/kg fenvalerate daily for 270 days. Treated (n=7) and controls (n=5) were vaccinated cultured rinderpest virus (TCRV) at 90 days. Humoral immunity invoked by the vaccine was assessed by hemagglutination antibody titre on day 7, 14, 28, 90 and 190 post vaccination. Our results suggest that mean hemagglutinin titers peaked 14th day after vaccinations in goats given pyrethroid and controls. However values in treated goats were consistently lower ~50-89% (P < 0.01). Delayed hypersensitivity values increased ~80-90% over 6-24h being ~44% lower (P < 0.05) in goats given pyrethroid by 24h. We found no reaction in goats inoculated with virus free dried spleen pulp. By microscopy skin of controls goats challenged with rinderpest allergen we observed severe congestion, edema and infiltration of mononuclear cells in the region of epidermis and dermis. Lymphocytic infiltration around blood vessels was marked whereas in those given pyrethroids lesion were less severe. Findings suggested that pyrethroids may suppress humoral immunity in goats vaccinated against rinderpest virus.

 

Keywords: Rinderpest, vaccine, pyrethroids, goat.


MAIN

 

FULL-TEXT (SUBSCRIBE OR PURCHASE TITLE)