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Online Journal of Veterinary Research©
Volume 26 (4): 306-312, 2022.
Abdul Salam Khoso1, Ahmed Nawaz Tunio1, Dildar Hussain Kalhoro2, Habibullah Janyaro3, Atique Ahmed Behan*4,
Majeed Hakeem Dhamrah4, Qurat Ul Ain5, Muhammad Ali Chandio6
1Department of Veterinary Surgery and Obstetrics, 2Department of Veterinary Microbiology, 3Department of Livestock Management, Faculty of Animal Husbandry and Veterinary Sciences Sindh Agriculture University Tandojam, Pakistan, 5Department of Anatomy, Peoples University of Medical and Health Sciences for Women, Nawabshah, 6Department of Veterinary Pathology, Shaheed Benazir Bhutto University of Veterinary and Animal Sciences, Sakrand, Pakistan.
*Correspondence: Email: email@example.com Cell #. +923003022105
Khoso AS, Tunio AN, Kalhoro DH, Janyaro H, Behan AA, Dhamrah MH, Ul Ain Q, Chandio MA., Oxidized regenerated cellulose and gelatin sponge hemostat for liver injury in rabbit model, Onl J Vet Res., 26 (4): 306-312, 2022. We report effect of oxidized regenerated cellulose (ORC) and gelatin sponge (GS) on bleeding, healing and liver function in New Zealand rabbits (Oryctolagus cuniculus). Two groups of 12 rabbits each were first subjected to a 1 cm incision liver wound and then inserted ORC and GS on right lobe. The animals were sacrificed at 12th and 18th day post-surgery when hemostatic score and clotting time were recorded. Hemostatic score at day 12 were 2.75±0.25 with GS and 2.51±0.65 with ORC and by day 18, 2.25±0.25 and 2.5±0.28 respectively. With GS or ORC clotting times were reduced ~28% by days 12 or 18 but serum bilirubin was 53-61% higher in rabbits given ORC. We found no effect on alkaline phosphatases. Glutamic pyruvic transaminase was 34-36% higher in animals given GS. Microscopy suggested that GS and ORC had been fully absorbed at necropsy but ORC induced faster healing. Findings suggest that GS was more efficient as hemostat but ORC induced faster healing.
Keywords: Liver injury, Hemostatic agent, Gelatin sponge, Oxidized regenerated cellulose, Rabbit. Raw data provided.