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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 25 (9):606-614, 2021.. .
Effect of Astragalus polysaccharide on erythrocyte-complement receptor type I adherence
in chickens inoculated with infectious bursal disease virus.
College of Veterinary Medicine and Animal Science, Shanxi Agricultural University, Taigu, Shanxi 030801,PRC, China.
Hongquan L., Effect of Astragalus polysaccharide on erythrocyte-complement receptor type I adherence in chickens inoculated with infectious bursal disease virus, Onl J Vet Res., 25 (9):606-612, 2021. Four groups of 10 one day old leghorn SPF chicks blood samples were tested for IBDV then inoculated 0.3ml infectious bursal disease virus (IBVD) (1) with or without 5 (2) or 10mg/kg (3) intramuscular Astragalus (APS). Controls were not treated (4). Cardiac blood was taken at 25-35 days for erythrocyte complement receptor type one (E-CR1) activity determined by erythrocyte-C3b receptor (E-C3b RR) and immune complex rosette rates (E-ICRR). In birds with IBVD not given APS incidence was 100% and mortality 24% whereas with 5mg Astralagus these values were ~55%, ~10% and 10mg/kg 43 and 7%, respectively. Compared with controls, E-C3bRR with IBVD but without APS was ~34-54% lower (P < 0.01) but given APS were not different. In chicks given 5mg/kg APS, E-C3bRR levels were lower than chicks not given APS (p<0.05) and with 10mg/kg E-C3bRR recovered more rapidly. Results suggest that APS may have prevented changes due to IBDV in erythrocyte-C3b receptor and immune complex rosette rates and reduced morbidity and mortality.
Key words: Astragalus polysaccharides; Chicken; IBDV; Erythrocyte; immune adherence.