2021-2032 All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under International copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editor.


Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X


Volume 25 (8):554-560, 2021

In silico epitope (T-228) rabies virus vaccine.


Tomar N Ra *, Marla S S a, Chandra Rb, Kumar Rc, Kumar Aa

aDepartment (s) of Molecular Biology and Genetic Engineering, ,bDepartment of Veterinary Microbiology, G. B. Pant university of Agriculture and Technology, Pantanagar and cAnimal Biotechnology section, Central Sheep and Wool Research Institute, Avikanagar, India




Tomar NR, Marla SS, Chandra R, Kumar R, Kumar A., In silico epitope (T-228) rabies virus vaccine, Onl J Vet Res., 25(8): 554-560, 2021. Accession FJ979833 was used to extract human epitopes from rabies virus glycoprotein database. Strongest binders with MHC molecules were determined by artificial neural network and stabilized matrix methods with highest scores subjected to clustal W alignment for conservancy. An epitope from position 228-236 (T-228) was identified as a novel T cell epitope revealing good MHC class I binding, processing and conservation in known rabies viruses. The findings suggest that it may be possible to generate a synthetic peptide vaccine against rabies but further research on G protein is required, including a search for additional linear epitopes.

Key words: Epitope vaccine, T cell epitopes, in-silico, rabies.