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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 25 (8):554-560, 2021
In silico epitope (T-228) rabies virus vaccine.
Tomar N Ra *, Marla S S a, Chandra Rb, Kumar Rc, Kumar Aa
aDepartment (s) of Molecular Biology and Genetic Engineering, ,bDepartment of Veterinary Microbiology, G. B. Pant university of Agriculture and Technology, Pantanagar and cAnimal Biotechnology section, Central Sheep and Wool Research Institute, Avikanagar, India
Tomar NR, Marla SS, Chandra R, Kumar R, Kumar A., In silico epitope (T-228) rabies virus vaccine, Onl J Vet Res., 25(8): 554-560, 2021. Accession FJ979833 was used to extract human epitopes from rabies virus glycoprotein database. Strongest binders with MHC molecules were determined by artificial neural network and stabilized matrix methods with highest scores subjected to clustal W alignment for conservancy. An epitope from position 228-236 (T-228) was identified as a novel T cell epitope revealing good MHC class I binding, processing and conservation in known rabies viruses. The findings suggest that it may be possible to generate a synthetic peptide vaccine against rabies but further research on G protein is required, including a search for additional linear epitopes.
Key words: Epitope vaccine, T cell epitopes, in-silico, rabies.