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OJVRTM
Online Journal of Veterinary
Research©
Volume 21(4):151-160, 2017.
Effect of a quercetin microemulsion
on anxiety markers in male NMRI mice.
Anayatollah
Salimi, Neda Sistani Karampour, Afrooz
Saadat Zadeh, Parnia Sadeghi.
Pharmaceutical
Sciences, Ahvaz Jundishapur University of Medical
Science, Ahvaz, Iran
ABSTRACT
Salimi A, Karampour NS, Zadeh AS, SadeghiP., Effect of a
quercetin microemulsion on anxiety markers in male
NMRI mice, Onl J Vet Res., 21(4):151-160, 2017. Quercetin a
plant flavonoid, has structural similarities with
benzodiazepine clonazepam modulators of gamma-aminobutyric acid receptors
(GABA) receptors. Groups of 8 male NMRI mice each were given 100, 200, 400
mg/kg quercetin microemulsion intraperitoneally (IP)
30 minutes before behavioral evaluation by elevated plus-maze (EPM) and open
field tests. Controls were given 10ml/kg micro-emulsion or 1mg/kg diazepam IP.
Mice given quercetin spent more time entry in open arms of EPM increasing at
100, 200 and 400 mg/kg (p<0.05). Increase in time and entry in EPM test
induced by quercetin was inhibited by 3mg/kg Flumazenil IP. In the open-field
test, no changes were seen in the locomotor activity in any dose of quercetin
compared with micro-emulsion vehicle controls. Results suggested that 200mg/kg
quercetin may induce anxiolytic effects similar to diazepam possibly by binding
to GABA receptors.