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OJVR
Online Journal of Veterinary Research©
Volume 13
(2):72-83, 2009. Extensively redacted 2017.
Effects of acetylcysteine
and dexamethasone on intraocular pressure and pupil
diameter in normal dogs
Sarchahi AA, DVM, PhD, and Harrazi A, DVM.
Department of Veterinary
Clinical Studies, School of Veterinary Medicine, Shiraz University
ABSTRACT
Sarchahi AA, Harrazi A. Effects of acetylcysteine and
dexamethasone on intraocular pressure and pupil diameter in normal dogs, Onl J Vet Res., 13 (2):72-83, 2009. We describe effect of acetylcysteine alone or with
dexamethasone on intraocular pressure (IOP) in normal dogs. Three groups of 5
dogs each were administered in the right eye, one drop of 3% acetylcysteine
(NAC) or 0.1% dexamethasone (DEXA) or 3% acetylcysteine with 0.1% dexamethasone
(NACDEXA), respectively. Mean IOP in dogs given DEXA and NACDEXA increased
compared to the saline treated left eye whereas in those given NAC, did
not. There were no significant
differences between the mean IOP of eyes treated with DEXA or NAC+DEXA. However
pupil diameters in dogs given NAC were lower compared to others. The results
suggest that acetylcysteine could be used in glaucomatous conditions. However
acetylcysteine with dexamethasone may increase intraocular pressure in normal
or glaucomatous dogs.
Key words: Acetylcysteine, Dexamethasone, Dog, Intraocular pressure,
Pupil diameter
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