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OJVRTM
Online Journal of Veterinary Research©
Volume
21(5):259-269, 2017.
Effect
of punicalagin nanofibrous
dressing on hydroxyproline during skin wound
healing in adult Wistar rats.
Shima Jalili1, Abutorab Tabatabee Naini2, Aminlari M.1*
1Department(s)
of Biochemistry, 2Surgery, School of Veterinary Medicine, Shiraz
University, Shiraz, Iran, 71345
ABSTRACT
Jalili S, Naini AT, Aminlari
M., Effect of punicalagin nanofibrous
dressing on hydroxyproline during skin wound healing in adult Wistar rats, Onl J Vet Res., 21(5):259-269,
2017. Punicalagin with nanofibers of
polyvinyl alcohol was produced by electrospinning and examined by scanning
electron microscopy (SEM). Following routine surgical preparation, a 3cm circle
of dorsal cervical skin was excised from groups of 10 rats each. Treated rats
were given nanofiber with punicalagin daily for 7
consecutive days and controls were given nanofiber but without punicalagin. At 7 and 20 days later, rats were euthanized
and biopsies were taken to determine hydroxyproline
content. Rats treated punicalagin showed
significant increases in hydroxyproline content
by 7 days (1.41 ±0.111 μg/mg tissue)
compared with controls (1.05 ±0.140 μg/mg
tissue). These results suggest that treatment with punicalagin
nanofibers may have increase collagen biosynthesis in rat wounds.
Keywords: Punicalagin,
wound healing, hydroxyproline, nanofiber,
electrospinning,
dressing.