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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 27 (12):679-686, 2023.

Effect of pumpkin seed (Cucurbita pepo L.) oil extract on 5, 10 and 15 day wound healing in Albino rats.


Shatha Mousa Mlaghee Al-Safi1, Noor alhuda K Al-Murshedy1,2, Saadia Salleh Mehdy Zieny1,2, Nadia KJ Al-Dawah1,2,

Israa Saadi Abdulameer1,2, Lubna Majid Mohammed1,2


1Department(s) Of Physiology and Pharmacology, 2Poultry, University of Al-Kufa, College of Veterinary Medicine, Najaf, Iraq.



Al-Safi SM, Al-Murshedy NAK, Mehdy Zieny SS, Al-Dawah NK, Abdulameer IS, Mohammed LM., Effect of pumpkin seed (Cucurbita pepo L.) oil extract on 5, 10 and 15 day wound healing in Albino rats, On J Vet Res., 27 (12):679-686, 2023. We report effect of pumpkin seed (Cucurbita pepo L.) oil extract of wound healing in 3 groups of 6 Albino rats each treated 5, 10 and 15 days. Under anaesthesia, one control saline and treatment wound were induced dorsally by scalpel 15 and metzenbaum scissors on each animal. Two 10X10mm circular full-thickness skin defect wounds (1010 mm) were made dorsally to border of panniculus carnosus. Rats were given 1ml/mg curcubita or saline (controls) topically for 5, 10 and 15 days. Skin thickness was assessed by Vernier calipers daily. For microscopy, skin samples were excised at necropsy by 5, 10 and 15 days treatment. Results suggest that compared with saline controls, rats given curcubita 10-15 days had ~40% (P < 0.05) less swelling. Compared with saline control skin, by microscopy, we observed re-epithelisation in rats given curcubita by 10 to 15 days. Results suggest oil pumpkin seeds may affect wound healing in albino rats.


Keywords: Pumpkin seed oil, Wound healing, Rats.