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OJVRTM
Online Journal of Veterinary Research©
Volume 22 (6):518-525, 2018.
Systematic review and meta-analysis protocol for Fasciola DNA vaccines.
Rama Jayaraj MVetSc PhD MPH1*, Chellan
Kumarasamy BTech2, David Piedrafita PhD3, Peter Smooker
PhD4.
1Charles
Darwin University, Darwin, Northern Territory 0909, 2University of
Adelaide, Adelaide, 3Faculty of Science and Technology Federation
University, Churchill, NZ, 4School of Science, RMIT University, Bundoora West Campus, Vic, Australia. *Rama.Jayaraj@cdu.edu.au
ABSTRACT
Jayaraj R, Kumarasamy C, Piedrafita D, Smooker P., Systematic
review and meta-analysis protocol for Fasciola DNA
vaccines, Onl J Vet Res., 22 (6):518-525, 2018. We describe a systematic review and meta-analysis
of immune response and protective efficacy of Fasciola DNA vaccines following PRISMA-P
(2015) guidelines (Moher et al. 2015). Multiple databases of published articles were independently
assessed for eligibility and meta-analysis to determine protection rate
estimates and pooled odds Ratio with 95% confidence intervals. Heterogeneity was
estimated by Higgins I2 statistic and publication bias via funnel
plots. A narrative synthesis of systematic review was done where meta-analysis was
not possible. Previous studies evaluated effectiveness of DNA encoding Fasciola vaccine
candidates, but results are highly variable due to heterogeneity in vaccines
and their protocols. We attempt to elucidate this observed heterogeneity for
development of DNA vaccines against fascioliasis.
Key Words: Fasciola hepatica, Fasciola gigantica,
systematic review, meta-analysis, DNA vaccines, protective efficacy.
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