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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 26 (3): 191-195, 2022.

Effect of prednisolone on thyroid and gonadotrophic hormones secretion in male domestic rabbits


1Barakat EM, 2Hassan M.


1Department of Chemistry, Faculty of Science, King Faisal University, Kingdom of Saudi Arabia, 2Department of Biochemistry, Faculty of Veterinary Medicine, University of Khartoum, Sudan




Barakat EM, Hassan M., Effect of prednisolone on thyroid and gonadotrophic hormones secretion in male rabbits, Onl J Vet Res., 26 (3): 191-195, 2022. Effect of 2.2 mg/kg body weight intramuscular injections of synthetic prednisolone on alternate days on serum thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone (TSH) and luteinizing hormone (LH) in adult rabbits are reported. Jugular blood was taken at days 6 and 12 of the experiment. Compared with 1% vehicle solution injected non-treated controls we found no effects after 3 prednisolone injections by 6th day on thyroid or TSH hormones. However, after 6 days serum T4 and T3 concentrations decreased 20-25% (P < 0.05). Serum LH declined 47 at days 3 and 76% by day 6 in rabbits given prednisolone. We find that injection of prednisolone was associated with substantial reduction in serum T4 and T3 and large declines in LH in rabbits. Results suggest that inhibition of LH secretion was controlled at hypothalamus and pituitary gland.


Key words: prednisolone, thyroid hormones, rabbits.