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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 25 (11):817-821, 2021.
Effect of prednisolone on thyroid and gonadotrophic hormone secretion in male domestic rabbits.
1Barakat EM and 2Hassan M.
1Department of Chemistry, Faculty of Science, King Faisal University, Kingdom of Saudi Arabia, 2Department of Biochemistry, Faculty of Veterinary Medicine, University of Khartoum, Sudan
Barakat EM, Hassan M., Effect of prednisolone on thyroid and gonadotrophic hormone secretion in male domestic rabbits, Onl J Vet Res., 25 (11):817-821, 2021. We report effect of 2.2 mg/kg intramuscular injections of prednisolone every 2nd day for 12 days on serum thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone (TSH) and leuteinzing hormone (LH) in male rabbits. Our findings show distinctly that 6 injections of prednisolone every 2nd day reduced serum levels of T4, 25% and T3, 20% (P < 0.05). In contrast with serum T4 and T3, we found no changes in serum TSH. Serum LH declined 47% at day 3 and 76% day 12 (P < 0.01). We surmise that prednisolone stabilized lysosomal enzymes reducing T4 and T3, pituitary failed to respond to low serum T4 and T3 accounting for unchanged serum TSH and prednisolone suppressed release of gonadotropin from hypothalamic and pituitary accounting for large declines in LH.
Key words: prednisolone, thyroid hormones, rabbits.