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OJVRTM
Online Journal of
Veterinary Research©
Volume 22 (5):382-392, 2018.
In vitro and in vivo
(rats) effect of pomegranate seed oil compared with ciprofloxacin
on pathogenic E. coli ICC
223 isolated from cattle with diarrhea.
Reham
N. Abdulridha and Orooba
M.S. Ibrahim.
Dept. of
Physiology & Pharmacology - College of Veterinary Medicine, Baghdad
University, Iraq.
ABSTRACT
Abdulridha RN, Ibrahim MS., In vitro and in vivo (rats)
effect of pomegranate seed oil compared with ciprofloxacin on pathogenic E.
coli ICC 223 isolated from cattle with diarrhea. Onl J Vet Res., 22 (5):382-392, 2018. We report In vitro and In Vivo effect in rats of pomegranate
seed oil compared with ciprofloxacin on pathogenic E. coli ICC 223 isolated
from diarrheic calves. In vitro antibacterial effect of 10, 20, 40, 60, 80 and
100 mg/ml pomegranate seed oil and ciprofloxacin (mcg/ml) were tested by
agar well diffusion with a 0.1 ml sterilized distilled water control. In Vivo,
groups of 8 rats each were infected and treated
orally with 200 or 400 mg/kg pomegranate seed oil or 14.28 mg/kg of
ciprofloxacin for 7 days. Controls were infected but not treated or not
infected but given distilled water for 7 days. In vitro E. coli was more sensitive to pomegranate seed oil
compared with ciprofloxacin. In vivo 400 mg/kg BW seed oil and 14.28 mg/kg ciprofloxacin reduced E. coli count
to normal by 7 days. Results suggest that 400mg/kg pomegranate seed oil at dose
400 mg/kg inhibited pathogenic E Coli. We surmise that this was due to
secondary metabolites in pomegranate known to have antibacterial activity.
Key word: Pomagrate, ciproflaxin,
rats, E. coli ICC 223, diarrhea, calves.
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