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OJVRTM
Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 27 (11): 640-650,
2023.
Polymerase PB2 protein influenza A virus target
Suchitra Kumari, Balaji
S Rao, Ankit Gupta, Narayana Murthy Lalam, Krishna Kant
Gupta.
Bioinformatics, NTHRYS Biotech Labs, Hyderabad, Andhra Pradesh,
India.
ABSTRACT
Kumari S, Rao BS, Gupta
A, Lalam NN, Gupta KK., Polymerase PB2 protein
influenza A virus target, Onl J Vet Res., 27 (11): 640-650, 2023. Avian influenza A subtype
H5N1 virus is a highly pathogenic (HPAI) strain widespread in birds, wild waterfowl and
shorebirds that can be managed with amantadine, oseltamivir,
rimantadine or zanamivir. We report target proteins essential for pathogen and
non-homologous virtual screening ligand-protein interaction by In
silico docking of 60 proteins of influenza A virus genome. Of these, we
detected polymerase PB2 to be essential for virus pathogenicity of non-homolog with
its human proteome. The structure of polymerase PB2 was retrieved from PDB (PDB ID: 2VY6) and we found analogue
CID505949 of zanamivir to efficiently bind with
protein through 9 hydrogen bonds.
Keywords:
Avian influenza; Polymerase PB2; Docking; ligands.
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