2023-2034 All Rights Reserved. Online Journal of Veterinary ResearchYou may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety toOJVR.This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X


Volume 27 (11): 640-650, 2023.

Polymerase PB2 protein influenza A virus target


Suchitra Kumari, Balaji S Rao, Ankit Gupta, Narayana Murthy Lalam, Krishna Kant Gupta.


Bioinformatics, NTHRYS Biotech Labs, Hyderabad, Andhra Pradesh, India.




Kumari S, Rao BS, Gupta A, Lalam NN, Gupta KK., Polymerase PB2 protein influenza A virus target, Onl J Vet Res., 27 (11): 640-650, 2023. Avian influenza A subtype H5N1 virus is a highly pathogenic (HPAI) strain widespread in birds, wild waterfowl and shorebirds that can be managed with amantadine, oseltamivir, rimantadine or zanamivir. We report target proteins essential for pathogen and non-homologous virtual screening ligand-protein interaction by In silico docking of 60 proteins of influenza A virus genome. Of these, we detected polymerase PB2 to be essential for virus pathogenicity of non-homolog with its human proteome. The structure of polymerase PB2 was retrieved from PDB (PDB ID: 2VY6) and we found analogue CID505949 of zanamivir to efficiently bind with protein through 9 hydrogen bonds.


Keywords: Avian influenza; Polymerase PB2; Docking; ligands.