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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 27 (11): 640-650, 2023.
Polymerase PB2 protein influenza A virus target
Suchitra Kumari, Balaji S Rao, Ankit Gupta, Narayana Murthy Lalam, Krishna Kant Gupta.
Bioinformatics, NTHRYS Biotech Labs, Hyderabad, Andhra Pradesh, India.
Kumari S, Rao BS, Gupta A, Lalam NN, Gupta KK., Polymerase PB2 protein influenza A virus target, Onl J Vet Res., 27 (11): 640-650, 2023. Avian influenza A subtype H5N1 virus is a highly pathogenic (HPAI) strain widespread in birds, wild waterfowl and shorebirds that can be managed with amantadine, oseltamivir, rimantadine or zanamivir. We report target proteins essential for pathogen and non-homologous virtual screening ligand-protein interaction by In silico docking of 60 proteins of influenza A virus genome. Of these, we detected polymerase PB2 to be essential for virus pathogenicity of non-homolog with its human proteome. The structure of polymerase PB2 was retrieved from PDB (PDB ID: 2VY6) and we found analogue CID505949 of zanamivir to efficiently bind with protein through 9 hydrogen bonds.
Keywords: Avian influenza; Polymerase PB2; Docking; ligands.