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OJVRTM
Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X

 

Volume 27 (11): 640-650, 2023.


Polymerase PB2 protein influenza A virus target

 

Suchitra Kumari, Balaji S Rao, Ankit Gupta, Narayana Murthy Lalam, Krishna Kant Gupta.

 

Bioinformatics, NTHRYS Biotech Labs, Hyderabad, Andhra Pradesh, India.

 

ABSTRACT

 

Kumari S, Rao BS, Gupta A, Lalam NN, Gupta KK., Polymerase PB2 protein influenza A virus target, Onl J Vet Res., 27 (11): 640-650, 2023. Avian influenza A subtype H5N1 virus is a highly pathogenic (HPAI) strain widespread in birds, wild waterfowl and shorebirds that can be managed with amantadine, oseltamivir, rimantadine or zanamivir. We report target proteins essential for pathogen and non-homologous virtual screening ligand-protein interaction by In silico docking of 60 proteins of influenza A virus genome. Of these, we detected polymerase PB2 to be essential for virus pathogenicity of non-homolog with its human proteome. The structure of polymerase PB2 was retrieved from PDB (PDB ID: 2VY6) and we found analogue CID505949 of zanamivir to efficiently bind with protein through 9 hydrogen bonds.

 

Keywords: Avian influenza; Polymerase PB2; Docking; ligands.


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