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OJVRTM

 

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 28 (8): 456-462, 2024.

          Effect of Pistacia atlantica hull oil on wound healing in rodents.

 

A Tabatabaii  Naeini, AR Hamidi, N Tanideh, S Nazifi.

 

School of Veterinary Medicine, Shiraz University, Shiraz University of Medical Sciences. Iran;

 

ABSTRACT

 

Tabatabaii  NN, Hamidi AR, Tanideh N, Nazifi S., Effect of Pistacia atlantica oils on wound healing in rodents, Onl J Vet Res., 28 (8): 456-462, 2024. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in Pistacia atlantica hull oil may inhibit free radicals/lipid peroxidation by malondialdehyde (MDA) in rodent skin wounds. Five groups of 6 Sprague Dawley male rats each were anesthetized with 2% xylazine  and 10% ketamine to create 2x2cm skin defect. After surgery rats were assigned as untreated and topical base gel controls, 5% and 10% pistacia oil in gels. Cardiac blood was taken at 3, 7, 10, 14 and 21 days into heparin for superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in red cells and malondialdehyde (MDA). For hemolysate, 0.5ml blood was centrifuged 700g 15 min for plasma and erythrocyte pellet for biochemitry. Compared with controls, in rats given pistacia oil,  SOD, GPX and CAT increased ~11-14% (P < 0.05) whereas MDA declined 14% over 21 days.    

 

Key words: Pistacia atlantica, bene hull oil, enzymatic antioxidants, lipid peroxidation, rat.

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