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OJVRTM
Online Journal of
Veterinary Research©
Volume 11 (1): 20-28,
2007. Redacted 2018.
Functional characterization of
catalytic site of Glucose-6-phosphate dehydrogenase gene in Bos indicus.
Ravikumar G, Satyendra PS, Amrita C, Kaur T, Narang R .
Molecular Cytogenetics Lab, Department of Animal Breeding and
Genetics, GAVASU, PAU Campus, Ludhiana-141004, India.
ABSTRACT
Ravikumar G, Satyendra PS, Amrita C, Kaur T, Narang R. Functional characterization of catalytic site of
Glucose-6-phosphate dehydrogenase gene in Bos indicus, Onl J Vet Res., 11(1) :
20-28, 2007. Glucose-6-phosphate-dehydrogenase (G6PD) is a ubiquitous enzyme
wherein NADPH has a crucial role in fatty acid biosynthesis and detoxification
of organic peroxides in cells. The structural gene for G6PD is X linked in
mammals and on the basis of its expression in many tissues can be regarded as a
typical housekeeping gene. In this study the coding sequence of Bos indicus G6PD mRNA having 1548
bp encoding 515 amino acids is reported. The
11-residue tryptic peptide structure containing the reactive lysine assigned
for the catalytic activity in G6PD was found to be strikingly similar in
baker’s yeast, bovine and human G6PD.
Key words: Sequence, Bos indicus, Glucose-6-phosphate-dehydrogenase, bovine
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