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OJVRTM
Online Journal of Veterinary Research©
Volume 18(4): 353-358, 2014. Redacted 2017.
Pharmacokinetics
of single oral and intravenous acetaminophen in pheasants (Phasianus
colchicus)
Shomali T1 (DVM, PhD), Mosleh N2 (DVM, PhD), Jalaei
J1(MS), Habibi H2(DVM,
PhD), Daneshi S2(DVM)
1Division
of Pharmacology and Toxicology, Department of Basic Sciences, 2Avian Disease
Research Center, School
of Veterinary Medicine, Shiraz University, Iran
ABSTRACT
Shomali T, Mosleh N, Jalaei J, Habibi H, Daneshi S., Pharmacokinetics
of single oral and intravenous acetaminophen in pheasants (Phasianus
colchicus), Onl J Vet Res.,
18(4): 353-358, 2014. Pharmacokinetics of a single oral and
intravenous dose of acetaminophen in pheasants is reported. Groups of pheasants
were gavaged or injected IV 10 mg/kg acetominaphen
in the wing vein. Blood samples were collected at 0, 5, 10, 20, 60, 120, 240
and 600 min after administration and acetaminophen was assayed colorimetrically. Oral bioavailability, elimination rate
constant, elimination half life and total clearance
were 73%, 0.37 h-1, 1.84 h and 0.65 l/kg.h
respectively. Elimination rate constant,
elimination half life and total clearance by
intravenous injection were 0.12 h-1, 5.84 h and 0.48 l/kg.h. Results suggest that acetaminophen has a relatively
high oral bioavailability, long elimination half-life and low total clearance
in common pheasants. Data may be used to optimize dosage regimens in this
species.
Key words: Acetaminophen, Pharmacokinetics, Common
pheasants.