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Online Journal of Veterinary Research©
Volume 22 (9):744-748, 2018.
Effect of branched chain amino acid and leucine supplement
on hydrogen peroxide toxicity in albino rabbits.
Fahad Saber Owain, Ahmed T Taha, Yaser AM Sulaiman.
Department of Animal Production, College of Agriculture, University of Tikrit, Iraq.
Owain FS, Taha AT, Sulaiman Y., Effect of branched chain amino acid and leucine supplement on hydrogen peroxide toxicity in albino rabbits, Onl J Vet Res., 22 (9):744-748, 2018. For two months, groups of 6 albino 4 to 5 month old rabbits each were given water with 0.02% hydrogen peroxide (H2O2) and standard feed with 0.05, 0.1 or 0.2% branched chain amino acid (BCAA) mix, and 0.1% leucine. Controls were 6 rabbits each given water with or without 0.02% H2O2 and standard diet. After fasting 12h, blood was taken at days 30 and 60 for glucose, albumin and total protein values. Compared with normal controls, blood glucose increased ~46-55mg/dl in H2O2 controls. At day 30, there were also increases in serum glucose in rabbits given BCAA compared with normal controls. However by 60 days in those given 0.1 or 0.2% BCAA, glucose values were comparable with normal values. Compared with normal controls there were very large falls (2.1-2.2mg/dl) in albumin in peroxide controls. There were also decreases in those supplemented BCAA except only in those given 0.1% BCAA by 60 days. Serum TPP declined sharply in peroxide controls (nearly 2 fold) compared with normal controls but in rabbits given 0.1 or 0.2% BCAA we found values similar to normal controls. Findings suggest that BBAA supplements at higher doses may provide some palliative effect on hydrogen peroxide toxicity in rabbits.
Key words: Rabbit, BCAA, glucose, total protein, albumin. Raw data provided.