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Online Journal of Veterinary Research©
Volume 22 (9):793-798, 2018.
Effect of branched chain amino acid supplement on
hydrogen peroxide kidney and liver toxicity in Albino rabbits.
Fahad Saber Owain, Ahmed T Taha, Yaser AM Sulaiman.
Department of Animal production, College of Agriculture, University of Tikrit.
Owain FS, Taha AT, Sulaiman Y., Effect of branched chain amino acid and leucine supplement on liver and kidney hydrogen peroxide toxicity in albino rabbits, Onl J Vet Res., 22 (9):793-798, 2018. For two months, groups of 6 albino 4 to 5 month old rabbits each, were given water with 0.02% hydrogen peroxide (H2O2) and standard feed with 0.05, 0.1 or 0.2% branched chain amino acid (BCAA) mix, and 0.1% leucine. Controls were 6 rabbits each given water with or without 0.02% H2O2 and standard diet. After fasting 12h, blood was taken at days 30 and 60 for serum enzymes. Compared with normal controls, serum alanine and aspartame transaminases, urea and creatinine increased (P < 0.05) in peroxide controls. There were 3 fold increases in creatinine suggesting kidney or protein toxicity. The serum values also increased in rabbits supplemented BCAA but less so (P < 0.05) than peroxide controls especially by Day 60. At day 60 ALT values in peroxide rabbits given BCAA were normal. Our results suggest that BCAA supplements at higher doses may reduce hydrogen peroxide induced liver an/or kidney toxicity in rabbits.
Key words: Amino acid, supplement, hydrogen peroxide, liver kidney enzymes, creatinine, urea, rabbit. Raw Data provided.