1994-2019. All Rights Reserved. Online
Journal of Veterinary Research. You may not store these pages in
any form except for your own personal use. All other usage or distribution is
illegal under international copyright treaties. Permission
to use any of these pages in any other way besides the before mentioned must be
gained in writing from the publisher. This article is exclusively
copyrighted in its entirety to OJVR publications. This article may be copied
once but may not be, reproduced or re-transmitted without the express
permission of the editors.
OJVRTM
Online Journal of Veterinary Research©
Established
1994
ISSN 1328-925X
Volume 22 (9):793-798, 2018.
Effect of branched chain amino acid supplement on
hydrogen peroxide kidney and liver toxicity in Albino rabbits.
Fahad Saber Owain, Ahmed T Taha,
Yaser AM Sulaiman.
Department of Animal production, College of Agriculture, University of
Tikrit.
ABSTRACT
Owain FS, Taha AT, Sulaiman Y., Effect of
branched chain amino acid and leucine supplement on liver and kidney hydrogen
peroxide toxicity in albino rabbits, Onl J Vet Res., 22 (9):793-798, 2018. For two months, groups
of 6 albino 4 to 5 month old rabbits each, were given
water with 0.02% hydrogen peroxide (H2O2)
and standard feed with 0.05, 0.1 or
0.2% branched chain amino acid (BCAA) mix, and 0.1% leucine. Controls were 6
rabbits each given water with or without 0.02% H2O2 and
standard diet. After fasting 12h, blood was taken at days 30 and 60 for serum
enzymes. Compared with normal controls, serum alanine and aspartame
transaminases, urea and creatinine increased (P < 0.05) in peroxide
controls. There were 3 fold increases in creatinine suggesting kidney or
protein toxicity. The serum values also increased in rabbits supplemented BCAA
but less so (P < 0.05) than peroxide controls especially by Day 60. At day
60 ALT values in peroxide rabbits given BCAA were normal. Our results suggest
that BCAA supplements at higher doses may reduce hydrogen peroxide induced
liver an/or
kidney toxicity in rabbits.
Key words: Amino
acid, supplement, hydrogen peroxide, liver kidney enzymes, creatinine, urea,
rabbit. Raw Data provided.
FULL-TEXT (SUBSCRIBE OR PURCHASE
TITLE)