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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
26 (9): 706-714, 2022.
Synthesis of β-lactams with
or without selenium for inhibition of staphylococcus
aureus.
Tanzeer Kaur PhD, Sonal Jamwal
MSc, Neeraj Khullar PhD, SS
Bari PhD
Panjab University, Chandigarh
ABSTRACT
Kaur T, Jamwal S, Khullar
N, Bari SS., Synthesis of β-lactams with or without selenium for
inhibition of staphylococcus aureus, Onl J Vet Res., (9): 706-716, 2022. Increased bacterial resistance to β-lactam antibiotics may be
countered by altered penicillin binding proteins. We report binding
interactions of β-lactams with altered penicillin binding serine thryonine kinase proteins (PASTA) verified by docking
simulations. Our 2D β-lactams were docked after energy minimization to exhibit
strong interaction with PBP 2b (2WAF) BL2 and PASTA 3PY9 binding with BL1, BL2,
BL6 and BL7 free binding energy of -6.501, -6.802 and -6.901 kcal/mol, respectively, greater than penicillin controls. Selenium
boosted hydrophobic binding of our β-lactams and reduced β-lactam nephrotoxicity.
Results were verified by In vitro
disk bacterial inhibition comparable to penicillin.
KEY WORDS-
β-lactams, Penicillin binding proteins, staphylococcus aureus,
Penicillin, Docking, In vitro inhibition
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