©1996-2019. All Rights
Reserved. Online Journal of Veterinary Research. You
may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJVR. This article may be
copied once but may not be, reproduced or re-transmitted without the express
permission of the editors. This journal satisfies the refereeing requirements
(DEST) for the Higher Education Research Data Collection (Australia). Linking:
To link to this page or any pages linking to this page you must link directly
to this page only here rather than put up your own page
OJVRTM
Online Journal of Veterinary Research©
Pathology of pituitary pars intermedia dysfunction
in a mare
Moaddab
SH¹, Siavosh Haghighi ZM²*,
Rahimi Feyli P¹, Miraghaii SH.³
Department (s) of clinical
sciences¹ and pathobiology², Razi University,
³Medical Biology Research Center, Kermanshah University of Medical Sciences, Iran
ABSTRACT
Moaddab SH, Siavosh Haghighi ZM, Rahimi Feyli P, Miraghaii SH., Pathology
of pituitary pars intermedia dysfunction in a mare, Onl
J Vet Res., 20(10):667-672, 2016. Equine pituitary pars intermedia dysfunction (PPID) is
a common endocrino-pathy in horses 15 years or older.
A 23 year old mare presented with a history of lethargy, hirsutism, weight loss
and muscular atrophy, pot belly, sway back, lameness, infertility, polyuria,
polydipsia, persistent lactation, excessive sweating, fat accumulation,
increased appetite, recurrent respiratory infection and severe laminitis. The
mare had been recumbent 3 days, despite good appetite and normal vital signs. Blood
tests showed hyperglycemia 18.1 mmol/lit; 326mg/dl,
extreme hyperinsulinemia 250µu/ml, marked glucosuria,
mild anemia, leukocytosis, neutrophilia and lymphopenia. Postmortem showed a
pituitary gland enlarged beyond the sella turcica, severely compressing the hypothalamus. A
yellow multinodular mass in the pars nervosa was sectioned to reveal the pars distalis
as a compressed sub-capsular ring of tissue on the rostral margin. A sharp line
of demarcation remained between the encapsulated neoplasm and compressed
atrophic pars distalis.
Microscopy of the mass revealed pleomorphic melanotropes
with eosinophilic granular cytoplasm and hyperchromatic nuclei. The findings
suggest PPID with secondary diabetes mellitus.
Keywords: Equine, Pituitary
Pars Intermedia Dysfunction, Melanotropes.