2023-2034 All Rights Reserved. Online Journal of Veterinary Research . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


OJVRTM

Online Journal of Veterinary Research

 

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 27 (11): 651-658, 2023.


Pharmacodynamics of intravenous paracetamol in buffalo calves.

 

Sushma Lalita Baxla, C Jayachandran, Birendra Kumar Roy, Ravuri Halley Gora, M Kumar.

 

College of Veterinary Science & A. H., Ranchi, Bihar Veterinary College Patna Jharkhand, India.

 

ABSTRACT

Baxla SL, Jayachandran C, Roy BK, Gora RH, Kumar M., Pharmacodynamics of intravenous paracetamol in buffalo calves, Onl J Vet Res., Volume 27 (11): 651-658, 2023. We report plasma and urine paracetamol levels after single 40mg/kg intravenous injection in 5 buffalo calves. Paracetamol was determined by spectrophotometry. Plasma levels were detected 4min to 2h whereas in urine up to 48h. Plasma distribution rate constant (α) 7.148 1.361h-1, half life (t1/2α) 0.11 0.01h, urine elimination (β) 0.965 0.136h-1 and half- life (t1/2β) 0.77 0.09h suggested rapid distribution and elimination. Rapid loss suggested low retention of 1.00 0.01h with area under curve 15.59 1.07mg/L.h and AUMC 16.09 2.56 mg/L.h2, K12 1.672 0.142 and K21 4.970 1.540h-1. We found thorough distribution of paracetamol due to high Vdarea (2.34 0.19L/kg) and tissue to plasma concentration ratio 0.59 0.13.

 

Key words : Disposition kinetics; urinary excretion, paracetamol, buffalo.


MAIN

 

FULL-TEXT (SUBSCRIPTION or PURCHASE TITLE)