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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 27 (11): 651-658, 2023.
Pharmacodynamics of intravenous paracetamol in buffalo calves.
Sushma Lalita Baxla, C Jayachandran, Birendra Kumar Roy, Ravuri Halley Gora, M Kumar.
College of Veterinary Science & A. H., Ranchi, Bihar Veterinary College Patna Jharkhand, India.
Baxla SL, Jayachandran C, Roy BK, Gora RH, Kumar M., Pharmacodynamics of intravenous paracetamol in buffalo calves, Onl J Vet Res., Volume 27 (11): 651-658, 2023. We report plasma and urine paracetamol levels after single 40mg/kg intravenous injection in 5 buffalo calves. Paracetamol was determined by spectrophotometry. Plasma levels were detected 4min to 2h whereas in urine up to 48h. Plasma distribution rate constant (α) 7.148± 1.361h-1, half life (t1/2α) 0.11± 0.01h, urine elimination (β) 0.965 ± 0.136h-1 and half- life (t1/2β) 0.77± 0.09h suggested rapid distribution and elimination. Rapid loss suggested low retention of 1.00 ± 0.01h with area under curve 15.59± 1.07mg/L.h and AUMC 16.09 ± 2.56 mg/L.h2, K12 1.672 ± 0.142 and K21 4.970 ± 1.540h-1. We found thorough distribution of paracetamol due to high Vdarea (2.34 ± 0.19L/kg) and tissue to plasma concentration ratio 0.59 ± 0.13.
Key words : Disposition kinetics; urinary excretion, paracetamol, buffalo.