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OJVRTM
Online Journal of Veterinary
Research©
Volume 17(8):450-459, 2013. Redacted 2017.
Effect of
Oseltamivir on avian influenza A virus (H9N2)
replication in cell culture
Pourghanbari, GH.1 Nili, H.1 Moattari, A.2
Mohammadi, A.3
1Avian Disease
Research Center, 3Department of Pathobiology, School of Veterinary
Medicine, 2Department of Bacteriology and Virology, Shiraz
University of Medical Science, Shiraz, Iran.
ABSTRACT
Pourghanbari GH, Nili H, Moattari A, Mohammadi A., Effect of Oseltamivir on avian influenza A
virus (H9N2) replication in cell culture, Onl J Vet
Res., 17(9):450-459,
2013.
M2 ion channel and neuraminidase inhibitors have been approved for the control
of avian influenza H9N2 subtype virus. The effect of Oseltamivir on virus (H9N2) activity in cell culture is reported. MDCK cell cultures
were inoculated with influenza virus titer and Oseltamivir was added at
different concentrations. Cell viability was determined using the MTT test.
Cytotoxicity concentration 50% of Oseltamivir was 0.5mg/ml and exhibited a dose
dependent anti avian influenza virus (A/chicken /Iran/772/1998(H9N2) activity.
Virus titers were reduced to 0.5-0.005 mg/ml. The finding suggests that
Oseltamivir should be investigated In
Vivo in poultry trials for the control and treatment of avian influenza
subtype H9N2.
Key words: oseltamivir,
antiviral, avian influenza, cell culture.
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