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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 22 (11):1086-1089, 2018.
Effect of chronic oral versus intraperitoneal beta aminobutyric acid on serum liver enzymes in male Sprague Dawley rats.
Eman Naji Saleh, Mohammed Abbas Jasim.
College of Education for Women, University of Anbar.
Saleh EN, Jasim MA., Effect of chronic oral versus intraperitoneal beta aminobutyric acid on serum liver enzymes in male Sprague Dawley rats, Onl J Vet Res, 22 (11):1086-1089, 2018. Three groups of five 3-4 month old male Sprague Dawley rats each were injected intraperitoneally (IP) daily 2ml saline with 1g (Group 1), 0.5g (2) or 0.25g/kg (3) beta amino butyric acid (BABA) for 28 days. IP controls were only injected 2ml saline (4). Another 3 groups were given the same concentrations of BABA by oral drench. Controls were drenched water for 28 days (8). At day 28 blood was taken for serum aminotransferases (ALT, ASP) and alkaline phosphatase (ALP) to determine liver damage, if any. Compared with water controls, our results suggest that BABA given at doses ranging from 0.25 to 1g daily for 28 days either as a drench or injected IP did not increase serum enzymes suggestive of liver damage. However, we did find significant declines (P < 0.01) in serum AST and ALT (-35 to 41%) in rats given BABA but no significant differences between methods of administration or doses used. The findings suggest that BABA is non-toxic to liver cells in rats and are consistent with previous results.
Key words: Non-protein amino acid, BABA, rat. Raw data provided.