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OJVRTM
Online
Journal of Veterinary Research©
Volume
21(4):189-197, 2017.
Effect
of chronic oral administration of Omeprazole on hepatocytes in rats (Rattus norvegicus)
Amer M Hussin
Assist.
Prof. Dr., College of Veterinary Medicine, Baghdad University, Iraq E-mail:
amer_hussain42@yahoo.com
ABSTRACT
Hussin AM., Effect of chronic oral administration of Omeprazole on
hepatocytes in rats (Rattus norvegicus),
Onl J Vet Res., 21(4):189-197, 2017. Effects
of prolonged oral administration of omeprazole on hepatic tissue in rats is described. Six rats each
were given 40mg/kg omeprazole, orally, once daily for 3 consecutive months. Six
non-treated rats were used as controls. At 3 months rats were sacrificed and
liver tissue excised and fixed for routine histological technique for light
microscopy. Hematoxylin, eosin and PAS stains were used and diameters of
hepatocyte components were measured by oculometer. In
hepatocytes of rats treated with omeprazole, apoptosis increased ~3% amongst
normal cells. Euchromatic nuclei of hepatocytes with
1-4 ring like hollow centered nucleoli occurred
frequently. Smaller bi-nucleated
hepatocytes (hyperplasia) increased in treated animals but hypertrophy was not
obvious. Results suggested that long term administration of 40 mg/kg omeprazole
may stimulate proliferation and apoptosis in hepatocytes.
Key words:
Omeprazole, rat, Cytological, histological, pathological, Liver.
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