2020-2032. All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


 

OJVRTM

Online Journal of Veterinary Research

Volume 24 (3):159-165, 2020.


Effect of Olea Europaea zinc oxide nanoparticles on gentamicin induced renal toxicity in adult female goats.

Aamir Maqtoof1, Baraa Njim Al-Okaily2 and Orooba MS Ibrahim3

 

1Department(s) of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Thi-Qar, 2,3College of Veterinary Medicine, University of Baghdad, Iraq.

 

ABSTRACT

 

Maqtoof A, Al-Okaily BN, Ibrahim OMS., Effect of Olea Europaea zinc oxide nanoparticles on gentamicin induced renal toxicity in adult female goats, Onl J Vet Res., 24 (3):159-165, 2020. Authors describe effects of olive leaf extract zinc nanoparticles formulation on gentamicin induced renal toxicity in Does. Four groups of 5 does each were injected intramuscular (IM) 25mg/kg gentamicin daily for 7 days (1), 10 g/Kg intraperitoneal (IP) zinc oxide olive nanoparticles daily 3 days (2), gentamicin 7 days and then nanoparticles 3 days (3) Another group was given nanoparticles with gentamycin for 3 days followed by gentamycin for 4 days (4). Controls were injected intramuscular saline (5). Blood and urine was taken for renal function markers. In goats treated gentamycin 7 days, serum creatinine increased (P < 0.05) ~14% but declined ~15% given both drugs for 3 days. Urine creatinine declined ~-40-44% with any treatment. Serum urea increased 20-25% in goats treated 7 days but declined ~-21% given both together. Blood urea declined in does given gentamycin or particles for 7 days animals but increased ~21-25% in those given both for 3 days. In urine, urea declined 25-51% in all groups expect those given on particles. GFR declined in 14-20% but increased in does given both treatments.Similarly we found that gamma glutaryl decline 19-36% but remained normal in goats given both. Our results suggest that administration of nanoparticles may have reduced renal toxicity of gentamycin in does when given together for 3 days.

 

Keywords: Olive Leaves extract, OLEZnONPs, goats, kidney functions.


MAIN

 

FULL-TEXT (SUBSCRIBE OR PURCHASE TITLE)