Effect of Olea Europaea zinc oxide nanoparticles on gentamicin induced renal toxicity in adult female goats.
Aamir Maqtoof1, Baraa Njim Al-Okaily2 and Orooba MS Ibrahim3
1Department(s) of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Thi-Qar, 2,3College of Veterinary Medicine, University of Baghdad, Iraq.
Maqtoof A, Al-Okaily BN, Ibrahim OMS., Effect of Olea Europaea zinc oxide nanoparticles on gentamicin induced renal toxicity in adult female goats, Onl J Vet Res., Authors describe effects of olive leaf extract zinc nanoparticles formulation on gentamicin induced renal toxicity in Does. Four groups of 5 does each were injected intramuscular (IM) 25mg/kg gentamicin daily for 7 days (1), 10 µg/Kg intraperitoneal (IP) zinc oxide olive nanoparticles daily 3 days (2), gentamicin 7 days and then nanoparticles 3 days (3) Another group was given nanoparticles with gentamycin for 3 days followed by gentamycin for 4 days (4). Controls were injected intramuscular saline (5). Blood and urine was taken for renal function markers. In goats treated gentamycin 7 days, serum creatinine increased (P < 0.05) ~14% but declined ~15% given both drugs for 3 days. Urine creatinine declined ~-40-44% with any treatment. Serum urea increased 20-25% in goats treated 7 days but declined ~-21% given both together. Blood urea declined in does given gentamycin or particles for 7 days animals but increased ~21-25% in those given both for 3 days. In urine, urea declined 25-51% in all groups expect those given on particles. GFR declined in 14-20% but increased in does given both treatments.Similarly we found that gamma glutaryl decline 19-36% but remained normal in goats given both. Our results suggest that administration of nanoparticles may have reduced renal toxicity of gentamycin in does when given together for 3 days.
Keywords: Olive Leaves extract, OLEZnONPs, goats, kidney functions.