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Online Journal of Veterinary Research©
Volume 22 (9):761-771, 2018.
Type 2 diabetic male patients with neuropeptide Y gene polymorphism in exon 2 +1128 (rs16139).
Mustafa Nuhad Jumaa Al-Darraji1 and Shireen Jazzar Ameen Al-Barzanji2.
1Al-Daraji College of Science, 2Al- Barzanji College of Education for Pure Sciences, Anbar University
Juma MN, Amin SJ., Type 2 diabetic male patients with neuropeptide Y gene polymorphism in exon 2 +1128 (rs16139). Onl J Vet Res., 22 (9):761-771, 2018. Chronic type II diabetes mellitus leads to changes in neuropeptide Y (NPY) gene expression and distribution. One hundred type 2 diabetic male patients and 50 healthy controls were tested for serum liver enzymes, cholesterol, triglycerides, lipids, low and high density LDL, and thyroid and kidney function tests with concurrent determination of multiple polymorphisms of the NPY gene at exon 2 +1128 (rs16139) by PCR-RFLP. We found increased (P <0.05) serum liver enzymes in all diabetic patients compared with controls except for aspartate transaminase. There were increased (P <0.05) urea, creatinine, uric acid, cholesterol, triglycerides and low density lipoprotein (LDL), but decreased HDL. In diabetics we found increased TSH and decreased tri-iodothyronine (T3) but no difference in T4 levels. At exon 2 +1128 (rs16139) the C allele was different in diabetic patients compared with the T allele which had higher frequency (P <000.1) in controls. Our findings suggest that the phenotypic polymorphism of single nucleotide region exon2 + 1128T/C (rs16139) may be associated with risk of type 2 diabetes and male susceptibility.
Key words: Type 2 diabetes, neuropeptide Y gene, polymorphism, rs16139.