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Online Journal of Veterinary Research©

 

Volume 18(7): 563-571, 2014. Redacted 2017.

Effects of intra-cerebro-ventricular ghrelin with or without nociceptin on feed intake in Ross cockerels

 

H Jonaidi DVM PhDa, MR Hajinezhad DVM PhDb, S Salari DVM PhDb, S Tajalli MScc, A Ghazanfari Moghadam PhDd

 

aDepartment of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, bDepartment of Basic Sciences, Faculty of Veterinary Medicine, University of Zabol, cFaculty of Agriculture, dBasic Sciences, Shahid Bahonar University of Kerman, Kerman, Iran

ABSTRACT

 

Jonaidi H, Hajinezhad MR, Salari S, Tajalli S, Ghazanfari Moghadam A., Effects of intra-cerebro-ventricular ghrelin with or without nociceptin on feed intake in cockerels Onl J Vet Res., 18(7): 563-571,  2014. Nociceptin N/OFQ agonists have been shown to increase food intake in mammals and birds. The effect of intra-cerebro-ventricular (ICV) injection of ghrelin with or without Nociceptin or Nociceptin antagonists (Nphe1) and Nociception (1-13) NH2 on the feed intake of feed deprived broiler cockerels is reported. ICV ghrelin in 3-h food-deprived chickens caused a dose-dependent decrease in food consumption, ICV 16nmol N/OFQ increased food intake in 3-h food deprived chickens, pre-treatment with ghrelin (0.6 nmol) completely abolished the effect of N/OFQ (16 nmol) on food Intake observed 60 and 120 min post treatment and cumulative food intake was significantly increased by 8 nmol nociceptin antagonist pre-treatment. The findings suggest that ghrelin decreased food intake and hyperphagic effects of N/OFQ by reducing N/OFQ  levels in the brain.

 

Keywords: Food intake; Ghrelin; nociceptin/orphanin FQ; Broiler cockerels.

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