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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X


Volume 28(4): 174-197, 2024.

GltC transcription binding DNA motif co-regulated genes in nitrogen fixing bacteria.


Khan F, Agrawal S, Mishra BN.


Institute of Engineering & Technology, India.


Khan F,  Agrawal S,  Mishra BN., GltC transcription binding DNA motif co-regulated genes in nitrogen fixing bacteria. Onl J Vet Res., 28 (4): 174-197, 2024. GltC transcription factor regulating expression of glutamate synthase (GS) has been verified in Bacillus subtilis, but it also represses transcription of its own gene. Glutamate synthase induces metabolism in nitrogen fixing bacteria. We report genome wide localization of GltC, binding and co-regulated genes. Upstream genomes of bacteria revealed genes with GltC motifs, and at lower thresholds, glutamate synthase GltC co-regulated genes can be attained in nitrogen fixing bacteria. The bacterial genomes also showed presence of GltC like proteins categorized as transcription regulators of LysR family. These predicted LysR proteins revealed identification of characteristic LysR domains, which were conserved with one another. The difference in binding motif patterns of GltC like motifs can be described to amino acid variation of LysR domain of the GltC like proteins who may cause expression of different set of proteins in different bacteria. There is further scope to perform specific comparative analysis of GltC binding motif elements in these nitrogen-fixing bacteria in order to describe the nature of patterns of expression of related co-regulated genes. Such computational studies are needed to be verified through precise experimentations.


KEY WORDS: GltC factor, Glutamic acid biosynthesis, computational localization of transcription factor, nitrogen-fixing bacteria.