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OJVRTM
Online Journal of Veterinary Research©
Volume 17 (2): 113-120, 2013. Redacted 2017.

Effect of Nitric oxide and GABA A receptors on feed intake in chickens

 

Hossein Jonaidi 1* (DVM, PhD), Mehdi Abbasnejad 2(PhD), Zahra Kohansal 2(MS)

 

1Basic Sciences Group of Veterinary Faculty, 2 Biology Group of Basic Sciences Faculty, Shahid Bahonar University, Kerman, Iran

SUMMARY

 

Jonaidi H, Abbasnejad M, Kohansal Z., Effect of Nitric oxide and GABA A receptors on feed intake in birds, Online J Vet Res., 17 (2): 113-120, 2013. Gamma aminobutyric acid (GABA) stimulates feed intake and Nitric oxide (NO) mediates feeding behavior in mammals and chickens by regulating transmission in the paraventricular nucleus (PVN) of the hypothalamus and nucleus accumbens. The effect of  an intra-cerebro-ventricular (ICV) injection of L-arginine, a NO precursor; bicuculline as a GABAA receptor antagonist; NG-nitro-L-arginine (L-NNA), a NO synthase inhibitor and muscimol as a GABAA receptor agonist on feed intake in broiler cockerels is described. L-NNA attenuated the effect of muscimol on feed intake. L-arginine partially weakened the decrease in feed intake induced by bicuculline. The effect of L-arginine was also attenuated by pretreatment with bicuculline 90 through 180 min post injection. These results suggest an interaction between NO and GABAergic systems via GABAA receptors on feed intake in the brain of chickens.

 

Key words: Nitric oxide, GABA, feed intake, chicken, interaction.

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