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OJVRTM
Online Journal of Veterinary Research©
Volume
20(8):571-577, 2016.
Effect of penicillamine on acute phase protein,
inflammation and tissue during acute nanoparticle silver toxicity in mice.
Fatemeh Namazi1,
Mehdi Fazeli2, Seyyed Rasoul Jalaee3, Yalda
Zolghadri2, Saeed Mohammadi Nezhad3,
Saeed Nazifi4,*
1Department of Pathobiology, 2Basic Sciences, 4Clinical
Studies, 3School of Veterinary medicine, Shiraz University, Shiraz,
Iran
ABSTRACT
Namazi F, Fazeli M, Jalaee SR, Zolghadri Y, Nezhad SM, Nazifi S., Effect of penicillamine
on acute phase protein, inflammation and tissue during acute nanoparticle
silver toxicity in mice, Onl J Vet Res., 20(8):571-577, 2016. LD50 of intraperitoneal (IP) nanoparticled silver in 4 groups of 6 BALB/c mice was
determined. Effect of penicillamine on nano particle toxicity in 6 groups of 6 female BALB/c mice
given 50 or 200 mg/kg concurrently, or 4 hours after was assessed. Six mice
were used as untreated controls. Haptoglobin (Hp), serum amyloid A (SAA), tumor necrosis factor alpha
(TNF-α), Interferon
gamma (IFN-γ) and interleukin 6 (IL-6) were assessed. Mice given nanosilver showed moderate degeneration of hepatocytes with
mononuclear cell infiltration and swelling, with interstitial nephritis, peribronchiolitis, bronchiolar
associated lymphatic tissue, interstitial pneumonia with macrophages and
lymphocytes infiltration in lumen of alveoli. No lesions were observed in brain
or heart. Severity of lesions appeared less in mice given penicillamine
and no lesions were found in controls. The LD50 for nanosilver
was 1500 PPM and there were significant increases in Hp,
SAA, TNF-α, IFN-γ and IL-6 in all groups except those receiving 200
mg/kg penicillamine or controls.
Key Words: Nanosilver, Acute phase proteins, Inflammatory mediator, Histopathology, Penicillamine.
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