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OJVRTM
Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
26 (11): 891-914,
2022.
Therapeutic
targets for Mycoplasma pneumoniae.
Gupta Sunil kumar1, Singh Sarita1, 2,, Gupta Manish
Kumar3, Pant K. K. 2, Seth P. K.1
1Bioinformatics
Centre, Biotech Park, Lucknow, India, 2Department of Pharmacology & Therapeutics, Chhatrapati Shahuji Maharaj
Medical University, Lucknow, Uttar Pradesh, India,
3Department of Bioinformatics, University Institute of Engineering
and technology, Chhatrapati Shahuji Maharaj University,
Kanpur, India
ABSTRACT
Kumar GS, Sarita S, Kumar
GM, Pant K, Seth PK, Therapeutic targets for Mycoplasma pneumoniae, Onl J Vet Res., 26 (11): 891-914, 2022. Whole
genome sequencing can identify therapeutic drug targets in pathogens. This is
done through subtractive genomics to identify essential genes for pathogen but
absent in host. Un-characterized proteins, present on the exposed surface of
pathogen can be drug targets. We used subtractive genomics to identify
therapeutic target in Mycoplasma
pneumoniae, an atypical pneumonia in humans. We
detected 688 protein coding genes with 297 absent in humans for M. pneumoniae. Analysis of non-human
homologous gene predicted 89 genes on surface of M. pneumoniae which could be vaccine or drug targets.
Keywords: therapeutic
target, homologs, chemotaxis, orthologous, Mycoplasma pneumoniae.
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