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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
26 (11): 891-914, 2022.
Therapeutic targets for Mycoplasma pneumoniae.
Gupta Sunil kumar1, Singh Sarita1, 2,, Gupta Manish Kumar3, Pant K. K. 2, Seth P. K.1
1Bioinformatics Centre, Biotech Park, Lucknow, India, 2Department of Pharmacology & Therapeutics, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India, 3Department of Bioinformatics, University Institute of Engineering and technology, Chhatrapati Shahuji Maharaj University, Kanpur, India
Kumar GS, Sarita S, Kumar GM, Pant K, Seth PK, Therapeutic targets for Mycoplasma pneumoniae, Onl J Vet Res., 26 (11): 891-914, 2022. Whole genome sequencing can identify therapeutic drug targets in pathogens. This is done through subtractive genomics to identify essential genes for pathogen but absent in host. Un-characterized proteins, present on the exposed surface of pathogen can be drug targets. We used subtractive genomics to identify therapeutic target in Mycoplasma pneumoniae, an atypical pneumonia in humans. We detected 688 protein coding genes with 297 absent in humans for M. pneumoniae. Analysis of non-human homologous gene predicted 89 genes on surface of M. pneumoniae which could be vaccine or drug targets.
Keywords: therapeutic target, homologs, chemotaxis, orthologous, Mycoplasma pneumoniae.