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OJBTM
Online Journal of
Bioinformatics ©
Volume 13 (1):50-58, 2012
In
silico homology model of mutated PTEN protein inducing meningioma
J. Kaur1, A.
Mohan1, S. Kumar1, Pallavi2, A. K. Malakar2*
1BCS Insilico Biology, 2National Bureau of
Fish Genetic Resources, Lucknow U. P., India.
ABSTRACT
Kaur
J, Mohan A, Kumar S, Pallavi A, Malakar
K., In silico homology model of mutated PTEN protein
inducing meningioma, Online J Bioinform,
13 (1):50-58, 2012. PTEN a tumor
suppressor gene, encodes protein as a dual specificity
protein lipid phosphatase regulating
phosphoinositol-3-kinase/Akt signal pathway causing
cell cycle arrest in G1-phase and apoptosis. A protein model was generated
using MODELLER with 1D5R:A template. The best model
had a DOPE score of -40224.32813 with 88.4% residues in the most favorable
region of a Ramachandran plot. In the generously
allowed and disallowed regions residues were 1.9% and 0.3% respectively. Loop
modeling using MODLOOP analyzed by PROCHECK 3.0 showed 88.4% residues in the
most favorable region and 0.0% in both generously allowed and disallowed
regions of a Ramachandran plot.
Key words: PTEN
protein, Meningioma, Homology Modeling, MODELLER.