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Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X


Volume 28(7): 405-409, 2024.

Micronucleated cells in sheep given nitroxynil and moxydectin


Adam ML1, Torres RA2, Sponchiado G1, Requião L1, Oms PA1


1Laboratório de Citogenética; Núcleo de Ciências Biológicas e da Saúde; Centro Universitário Positivo, UnicenP. 2Laboratório de Genômica Evolutiva e Ambiental, Departamento de Zoologia, UFPR. Centro Politécnico; Jardim das Américas; Curitiba, PR, Brazil. CEP 81531-990. †Author for correspondence: ratorres@ufpr.br




Adam ML, Torres RA, Sponchiado G, Requião L, Oms PA Micronucleated cells in sheep given nitroxynil and moxydectin, Onl J Vet Res., 28 (7): 405-409, 2024. Micronuclei assays were used to determine the genotoxicity of 1ml/50kg nitroxynil and 1ml/25kg moxidectin at 45 and 105 days of age, respectively, in 2 groups of 5 Suffolk sheep each. Blood smears were made on sterile, dry slides, fixed with absolute methanol and maintained at room temperature for 24 hours.  Slides were immersed in Giemsa solution and tested 1000 cells from each sheep. Micronucleated cells were counted by optical microscope with oil-immersion lens. There was no significant difference between treated and controls (untreated newborn) animals in frequency of micronucleated cells. 


KEY WORDS: micronucleus assays, genoxicity, anthelmintics, sheep.