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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume 28(7):
405-409, 2024.
Micronucleated cells in sheep
given nitroxynil and moxydectin
Adam ML1,
Torres RA2, Sponchiado G1, Requião L1, Oms PA1
1Laboratório
de Citogenética; Núcleo de Ciências Biológicas e da Saúde; Centro Universitário
Positivo, UnicenP. 2Laboratório de Genômica Evolutiva e Ambiental, Departamento
de Zoologia, UFPR. Centro Politécnico; Jardim das Américas; Curitiba, PR,
Brazil. CEP 81531-990. †Author for correspondence: ratorres@ufpr.br
Adam ML, Torres RA, Sponchiado
G, Requião L, Oms PA Micronucleated cells in sheep given nitroxynil and moxydectin, Onl J Vet Res., 28
(7): 405-409, 2024. Micronuclei assays were used to determine the
genotoxicity of 1ml/50kg nitroxynil
and
1ml/25kg moxidectin at 45 and 105 days of age,
respectively, in 2 groups of 5 Suffolk sheep each. Blood smears were made on
sterile, dry slides, fixed with absolute methanol and maintained at room
temperature for 24 hours. Slides were immersed
in Giemsa solution and tested 1000 cells from each sheep. Micronucleated
cells were counted by optical microscope with oil-immersion lens. There was no significant
difference between treated and controls (untreated newborn) animals in frequency
of micronucleated cells.
KEY WORDS:
micronucleus assays, genoxicity, anthelmintics,
sheep.