Effect of Prosopis farcta root on blood lipids and aorta in rabbits fed cholesterol for 30 days

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Online Journal of Veterinary Research©

Volume 20(1):37-44, 2016. Redacted 2017.

Effect of Prosopis farcta root on blood lipids and aorta in rabbits fed cholesterol for 30 days.

Mohammad Reza Saidi¹, Shahram Miraghaee^2,3*, Mohammad Hosein Farzaei^2,3, Atefeh Babaei^2,3, Bahareh Mohammadi^2,3,

Mohammad Taher Bahrami^2,3, Gholamreza Bahrami^2,3

¹Imam Ali Hospital, ^bMedical Biology Research Center ^cFaculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

ABSTRACT

Saidi MR, Miraghaee S, Farzaei MH, Babaei A, Mohammadi B, Bahrami MT, Bahrami G, Effect of Prosopis farcta root on blood lipids and aorta in rabbits fed cholesterol for 30 days. 20(1):37-44, 2016. Prosopis farcta root may affect atherosclerosis in humans. Four groups of 8 young male New Zealand white (NZW) rabbits were fed standard pellet or gavaged 2% cholesterol daily. The rabbits were gavaged distilled water (controls), simvastatin 0.6mg/kg or P. farcta root extracts 500 mg/kg/day for 30 days. Blood samples were assessed for total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL). At necropsy, aortas were assessed for fatty streak and atheromatous plaque factors. Serum lipids increased in high cholesterol groups compared with controls (P<0.05). P. farcta root reduced TCl, HDL, TG, LDL, and VLDL levels compared with same values in rabbits fed a high cholesterol diet (P < 0.050). Atheromatous plaques composed of fatty streaks with lipid-laden macrophages (foam cells), extensive necrotic area, and calcification were formed in the thoracic and abdominal aortas in hypercholestrolemic rabbits.

Keywords hypercholesterolemia, New Zealand White rabbit, atherosclerosis, Cholesterol, Prosopis farcta.

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