1994-2020. All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors.
Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 22 (11):1054-1061, 2018.
Serum electrolytes, gluthathione and malondialdehyde in rats injected gentamycin and gavaged Morus alba leaf extract.
Mojtaba I Hashim and Salma J Asker.
College of Veterinary Medicine , University of Baghdad.
Hashim MI, Asker SJ., Serum electrolytes, gluthathione and malondialdehyde in rats injected gentamycin and gavaged Morus alba leaf extract, Onl J Vet Res., 22 (11):1054-1061, 2018. Five groups of 15 swiss albino male rats each were injected 5mg/kg gentamicin sulphate intramuscularly (IM) with 200 or 400mg/kg Morus alba ethanolic leaf extract daily for 5 and 10 days or 5mg/kg gentamicin IM with 200mg/kg Vitamin C orally (Sham controls 4). Water controls (5) were given distilled water orally daily for 5 and 10 days. Five rats from each group were left 10 days more without any additional treatments as recovery period. Animals of each group (n=5) were sacrificed at day 5, 10 and 20 days and blood was taken for serum biochemistry, gluthathione (GSH) and Maloldehyde (MDA). Compared with water controls our results showed 5 to 13% declines in serum sodium and very large declines (-22 to -47%) in serum potassium in rats given gentamycin with no recovery by day 20. In rats given gentamycin with 400mg/kg MA or and Vitamic C serum Na and K remained similar to controls. We also observed declines in serum calcium, magnesium and GSH but increased (P<0.05) serum MDA at days 5, 10 and even after 10 days of recovery. We find that daily 5mg/kg gentamycin IM induces severe possibly permanent changes in serum electrolytes in rats.
Key-Words: Morus alba, gentamycin, toxicity, electrolytes, gluthathione, malondialdehyde. Raw data provided.