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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume 22 (11):1054-1061, 2018.
Serum electrolytes, gluthathione
and malondialdehyde in rats injected gentamycin and gavaged Morus alba leaf extract.
Mojtaba I Hashim and Salma J
Asker.
College of Veterinary Medicine ,
University of Baghdad.
ABSTRACT
Hashim MI, Asker SJ., Serum electrolytes, gluthathione
and malondialdehyde in rats injected gentamycin and gavaged Morus alba leaf extract, Onl J Vet Res., 22 (11):1054-1061, 2018. Five groups of 15 swiss albino male rats each were injected 5mg/kg gentamicin
sulphate intramuscularly (IM) with 200 or 400mg/kg Morus alba ethanolic
leaf extract daily for 5 and 10 days or 5mg/kg gentamicin IM with 200mg/kg Vitamin
C orally (Sham controls 4). Water controls (5) were given distilled water
orally daily for 5 and 10 days. Five rats from each group were left 10 days
more without any additional treatments as recovery period. Animals of each group
(n=5) were sacrificed at day 5, 10 and 20 days and blood was taken for serum biochemistry,
gluthathione (GSH) and Maloldehyde
(MDA). Compared with water controls our
results showed 5 to 13% declines in serum sodium and very large declines (-22
to -47%) in serum potassium in rats given gentamycin with no recovery by day 20.
In rats given gentamycin with 400mg/kg MA or and Vitamic
C serum Na and K remained similar to controls. We also observed declines in
serum calcium, magnesium and GSH but increased (P<0.05) serum MDA at
days 5, 10 and even after 10 days of recovery. We find that daily 5mg/kg gentamycin
IM induces severe possibly permanent changes in serum electrolytes in rats.
Key-Words: Morus alba, gentamycin,
toxicity, electrolytes, gluthathione, malondialdehyde. Raw data provided.
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