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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 26 (4): 302-305, 2022.
Effect of methanolic extract of momordica dioica on phenytoin induced cognitive impairment in albino mice.
Deshpande PS, Page AB.
School of Pharmacy and Technology Management, SVKM’s, NMIMS, Shirpur, India
Deshpande PS, Page AB, Effect of methanolic extract of momordica dioica on phenytoin induced cognitive impairment in albino mice, Onl J Vet Res., 26 (4): 302-305, 2022. Four groups of five 20-30gm albino mice were gavaged daily for 7 days with 25mg/kg phenytoin (1), 500mg/kgf methanolic extract of Momordica dioica (2), both then followed by 25mg/kg phenytoin (3) or 12.5mg/kg phenytoin (4). Controls were gavaged 10ml/kg vehicle. Cognition and memory were tested by elevated plus maze, pole climb for avoidance, maximal electroshock and passive avoidance. Compared with controls (P < 0.05) we found extract per se reduced convulsions 70% and given with phenytoin 55-68%. Time spent in open arm maze increased 12% in mice gavaged phenytoin but declined 11% with extract and reduced time in open arms 53%, and both 35-75%. Entries increased 55-63% with extract. Pole avoidance declined 79% in mice given phenytoin but in those given extract we found no effect. Findings suggest extract inhibited effect of phenytoin on mice cognition.
Key-words: Cognition, mice, phenytoin, momordica dioica.