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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X


Volume 26 (10): 722-728, 2022.


Effect of foxtail millet (Setaria italica) on kidney function and serum electrolytes in sheep and goats


Arash Omidi1, Fateme Izadi Yazdanabadi2, Ukabed Esmaeilpour3


1Department of Animal Health Management, Veterinary School, Shiraz University, 2Department of Animal Science, Faculty of Agriculture, University of Tabriz, 3Department of Animal Science, Faculty of Agriculture, University of Birjand.




Omidi A, Yazdanabadi FI, Esmaeilpour U., Effect of foxtail millet (Setaria italica) on kidney function and serum electrolytes in sheep and goats, Onl J Vet Res., Volume 26 (10): 722-728, 2022. Foxtail millet may induce hepato-toxic photosensitization in ruminants. Six goats and sheep were fed ad libitum alfalfa and tap water for 7 days and then given foxtail millet 49 days. Jugular blood and body weight were taken every 7 days for serum blood urea nitrogen (BUN), creatinine, sodium, potassium, phosphorus, magnesium and EDTA blood hematocrit and hemoglobin. The animals were then sacrificed for microscopy of renal tissue. At end of study, 3 lambs exhibited hepatogenic photosensitization with erosions and ulcers in head, face, ears, eyelids, hyperemia, yellow sclera and conjunctivis. Clinical and dermal signs in goats were milder but in 3 we found hyperemia, mild yellow sclera and conjuntivitis. Both had loose stools from 2nd week. By microscopy of kidney tissue, we observed moderate to severe congestion with blue-purple sediments in collecting ducts and mild to severe degeneration of convoluted tubules in sheep but in goats renal congestion. Compared with controls, over 7 weeks, serum BUN declined 26-68% but creatinine increased ~17%, sodium 4-7%, magnesium 33-38%, phosphorus 18-36% , PCV and Hg ~32-36% (P < 0.05). Results suggest that foxtail millet may induce renal toxicity and grazing should be limited to 1 week.




Keywords: foxtail millet, sheep and goat, kidney lesions, hepatotoxic photosensitization.