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OJVRTM
Online Journal of Veterinary Research©
Volume 20(6):377-388, 2016.
Effect of intranasal and intramuscular midazolam-flumazenil on sedation and recovery in Lohmann layers.
Mohammad Masoudi DVM, DVSc; Ali Baniadam DVM, DVSc; Hosein Najafzadeh
Varzi DVM, PhD; Mansour Mayahi DVM,
DVSc.
Faculty of Veterinary Medicine, Shahid Chamran University of
Ahvaz, Ahvaz, Iran
ABSTRACT
Masoudi M, Baniadam
A, Varzi HN, Mayahi M.,
Effect of intranasal and intramuscular midazolam-flumazenil on sedation and
recovery in Lohmann layers, Onl
J Vet Res., 20(6):377-388, 2016. Sedation by intranasal (IN) and intramuscular
midazolam (MDZ) and recovery by IN and intramuscular flumazenil (FLU) in Lohman
layers are described. Three groups of 8 Lohmann layers
each were administered
6mg/kg midazolam and/or 0.05 mg/kg flumazenil by IN and leg or
pectoral muscles. Sedation by IN and pectoral muscle routes occurred sooner than through
leg muscle injections. FLU neutralized sedation by MDZ in all birds. Response
to stimulus factor in layers treated IN was shorter than in other groups.
Righting reflex was not affected by any route treatment reaching a maximum
within 20 minutes. Heart rate in layers injected in leg muscles was less than
other groups and respiratory rate was reduced further by IN administration
compared with other routes. Findings suggested that IN and pectoral muscle
midazolam administrations to Lohmann layers induced faster
onset, but shorter sedation.
Keywords: Midazolam, Flumazenil, Sedation, Recovery,
Poultry.
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