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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 27 (4): 238-243, 2023.
Molecular docking substrate stabilization for Microsporum canis keratinase
MVK Karthik, Hanan Syed, Tridisha Goswami, Pratyoosh Shukla
Birla Institute of Technology, Mesra, Jharkhand, India.
Karthik MVK, Syed H, Goswami T, Shukla P., Molecular docking substrate stabilization for Microsporum canis keratinase, Onl J Vet Res., 27 (4): 238-243, 2023. Keratinophilic fungi degrade keratin. In this study we modeled keratinase of Microsporum canis and confirmed its accurary with a RMS Z score (1.432) using PROVE software. Molecular docking between modeled keratinases from species of keratinophilic fungi viz. Microsporum canis with different types of keratins as substrates was performed with scores of -451.89 kj/mol and -262.37 kj/mol, respectively. Arg1031 is conserved in keratinase while interacting with both keratins
Key words: Keratinophilic fungi, keratin, keratinase, Microsporum canis, molecular docking.