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OJVRTM

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X

 

Volume 27 (4): 238-243, 2023.


Molecular docking substrate stabilization for Microsporum canis keratinase

 

MVK Karthik, Hanan Syed, Tridisha Goswami, Pratyoosh Shukla

 

Birla Institute of Technology, Mesra, Jharkhand, India.

 

ABSTRACT

 

Karthik MVK, Syed H, Goswami T, Shukla P., Molecular docking substrate stabilization for Microsporum canis keratinase, Onl J Vet Res., 27 (4): 238-243, 2023. Keratinophilic fungi degrade keratin. In this study we modeled keratinase of Microsporum canis and confirmed its accurary with a RMS Z score (1.432) using PROVE software. Molecular docking between modeled keratinases from species of keratinophilic fungi viz. Microsporum canis with different types of keratins as substrates was performed with scores of -451.89 kj/mol and -262.37 kj/mol, respectively. Arg1031 is conserved in keratinase while interacting with both keratins

 

Key words: Keratinophilic fungi, keratin, keratinase, Microsporum canis, molecular docking.


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